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The quest for autism’s causes, and what it reveals about all of us

Emily Willingham Knowable Magazine As alarm grew over autism prevalence at the turn of this century, there was much public talk of a growing “epidemic.” That language has since softened, and it is now clear that many autistic people were there all along, their condition unrecognized until relatively recently. But what is the cause? The emerging narrative today is that there is no single cause—rather, multiple factors, roughly sorted into the categories of genetics and environment, work together in complex ways. Because of this complexity and the hundreds of gene variants that have been implicated, developing human brains may follow many possible paths to arrive at a place on the autism spectrum. And this may help explain something true about autism: It varies greatly from one person to the next. As clinicians view it, autism involves communication deficits and formulaic, repetitive behaviors that present obstacles to establishing conventional relationships. The…

Recent Autism Studies in the News: Overpromising, Big Time

Emily Willingham, Ph.D daisymayfattypants.blogspot.com biologyfiles.wordpress.com Two autism studies made recent headlines: How a Gene Mutation Leads to Autism and Proximity to Freeway Increases Autism Risk. The first is a close-up on a particular gene using mice as a model and the other is an epidemiological study. The mouse study examined a gene/protein known as SHANK3, which has been implicated previously in autism. The epidemiological study looked at correlations between living near highways and autism rates. Let’s take a look at the mouse study [PDF] first. SHANK3 has emerged as a protein of interest because of its roles in nerve connectivity. Researchers also have found that losing one copy of the SHANK3 gene — normally, people have two functional copies — can be associated with behaviors linked to autism. The authors of this new mouse study, which is being published in Molecular Autism, decided to knock out one Shank3 copy in…